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Research groups have just started to apply EMT-related markers in their studies on CTCs in cancer patients.In the present review, we summarize and discuss the current state of investigations on CTCs in the context of research on EMT/MET.The reverse process of mesenchymal–epithelial transition (MET) might play a crucial role in the further steps of metastasis when circulating tumour cells (CTCs) settle down in distant organs and establish (micro-)metastasis.Nevertheless, the exact mechanisms and interplay of EMT and MET are only partially understood and their relevance in cancer patients is unclear.Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, IN 46556, USACorrespondence: ZT Schafer, Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 222 Galvin Life Science Center, Notre Dame, IN 46556, USA.Tel: 1 5; Fax: 1 5; E-mail: [email protected] 27 March 2014; Revised 7 November 2014; Accepted 10 November 2014Advance online publication 19 December 2014Edited by E Gottlieb Inflammatory breast cancer (IBC) is a rare and highly invasive type of breast cancer, and patients diagnosed with IBC often face a very poor prognosis.

Erb B2 and EGFR knockdown in KPL-4 and SUM149 cells, respectively, causes decreased colony growth in soft agar and increased caspase activation following ECM detachment.

IBD-related cancer is relatively uncommon in childhood; however, this is also a subject of debate.

There are no data on the incidence of IBD-related cancer in Europe as a whole; there are only separate studies.

Also perplexing is why the disease disproportionately strikes African American women and women of North African or Middle Eastern descent.

Even its name needs deciphering; the typical redness and swelling of the breast seen in IBC that superficially resemble inflammation are actually due to lymph ducts that have been clogged with tumor cells.




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